136963-58-1Relevant articles and documents
SYNTHESE ET STRUCTURE DE CHLOROETHYLSULFONYL-ET SULFOXYLUREES DERIVEES DE L'ISOCYANATE DE CHLOROSULFONYLE
Dewynter, Georges,Montero, Jean-Louis,Agoh, Bernadette,Leydet, Alain,Doukhan, Gerard
, p. 223 - 237 (2007/10/02)
IN the field of research of alkylo-carbamoyling non-nitrosed compounds, are presented here two news series which associate ureido group with 2-chloroethyl substituant.Both title's compounds are synthesized from chlorosulfonyl isocyanate (C.S.I.), by regioselective methods.The structures are established by IR, NMR 1H and 13C, Mass spectrometry and RX diffraction data.The biological evaluation towards L1210 does not show significant antimitotic properties for these ureas.This fact is certainly in connection with their polar confirmed structure. Key words: Chlorosulfonyl isocyanate; chloroethylsulfonylureas; chloroethylsulfoxylureas; crystallographic data; antimitotic sceening.