1370024-14-8

Basic information

• Product Name: 7-bromo-2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl] imidazo[2,1-b][1,3] benzothiazole
• CAS NO: 1370024-14-8
• Molecular Weight: 481.437
• Mol File: 1370024-14-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-bromo-2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl] imidazo[2,1-b][1,3] benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl] imidazo[2,1-b][1,3] benzothiazole(1370024-14-8)
• EPA Substance Registry System: 7-bromo-2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl] imidazo[2,1-b][1,3] benzothiazole(1370024-14-8)

Safety Data

• Hazardous Substances Data: 1370024-14-8(Hazardous Substances Data)

Upstream product

• 106-40-1 4-bromo-aniline 
• 33420-82-5 2-(4-methoxy-phenyl)-1-(4-methylsulfanyl-phenyl)ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 15864-32-1 2-amino-6-bromobenzothiazole 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant articles and documents

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.