137109-40-1

Basic information

• Product Name: 7-methoxy-2-(p-tolyl)-2,3-dihydrochromen-4-one
• Synonyms: 7-methoxy-2-(p-tolyl)-2,3-dihydrochromen-4-one
• CAS NO: 137109-40-1
• Molecular Weight: 268.312
• Mol File: 137109-40-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-methoxy-2-(p-tolyl)-2,3-dihydrochromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-2-(p-tolyl)-2,3-dihydrochromen-4-one(137109-40-1)
• EPA Substance Registry System: 7-methoxy-2-(p-tolyl)-2,3-dihydrochromen-4-one(137109-40-1)

Safety Data

• Hazardous Substances Data: 137109-40-1(Hazardous Substances Data)

Upstream product

• 5751-52-0 7-methoxy-4H-chromen-4-one 
• 5720-05-8 4-methylphenylboronic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 137109-37-6 1-(2-hydroxy-4-methoxyphenyl)-3-(p-tolyl)prop-2-en-1-one 

Downstream Products

• 138469-48-4 C₂₄H₂₃NO₅S 

Relevant articles and documents

Rhodium/chiral diene-catalyzed asymmetric 1,4-addition of arylboronic acids to chromones: A highly enantioselective pathway for accessing chiral flavanones

Chromone has been noted to be one of the most challenging substrates in the asymmetric 1,4-addi-tion of α,β-unsaturated carbonyl compounds. By employing the rhodium complex associated with a chiral diene ligand, (R,R)-Ph-bod, the 1,4-addition of a variety of aryl-boronic acids was realized to give high yields of the corresponding flavanones with excellent enantioselectivities (≥97% ee, 99% ee for most substrates). Ring-opening side products, which would lead to erosion of product enantioselectivity, were not observed under the stated reaction conditions.

A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.