1371209-21-0

Basic information

• Product Name: C₂₀H₂₄N₄O₃
• CAS NO: 1371209-21-0
• Molecular Weight: 368.436
• Mol File: 1371209-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₄N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₄N₄O₃(1371209-21-0)
• EPA Substance Registry System: C₂₀H₂₄N₄O₃(1371209-21-0)

Safety Data

• Hazardous Substances Data: 1371209-21-0(Hazardous Substances Data)

Upstream product

• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 198281-55-9 3-(4-methyl-piperazin-1-ylmethyl)-phenylamine 
• 96-98-0 4-methyl-3-nitrobenzoic acid 

Downstream Products

• 1393911-35-7 (E)-4-methyl-N-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-3-(3-(pyridin-3-yl)acrylamido)benzamide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR-ABL kinase

A series of acrylamide analogues were designed and synthesized from Imatinib and Nilotinib as novel BCR-ABL inhibitors by application of the principle of nonclassical electronic isostere. All new compounds were evaluated for their inhibitory effects on the activity of BCR-ABL kinase and the proliferation of K562 leukemia cancer cells in vitro. The acrylamide analogues in which the substituent in C ring was trifluoromethyl group were identified as highly potent BCR-ABL kinase inhibitors. Compound 13f exhibited an IC 50 value as low as 20.6 nM in ABL kinase inhibition and an IC 50 value of 32.3 nM for antiproliferative activity, about 10.5-fold and 12-fold lower than those of Imatinib respectively. These results suggest that compound 13f is a promising candidate as a novel BCR-ABL kinase inhibitor for further development.