137121-87-0

Basic information

• Product Name: α/β-D-thymidine
• Synonyms: α/β-D-thymidine
• CAS NO: 137121-87-0
• Molecular Weight: 242.232
• Mol File: 137121-87-0.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: α/β-D-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: α/β-D-thymidine(137121-87-0)
• EPA Substance Registry System: α/β-D-thymidine(137121-87-0)

Safety Data

• Hazardous Substances Data: 137121-87-0(Hazardous Substances Data)

Upstream product

• 65-71-4 thymin 
• 1062488-85-0 C₂₆H₂₆N₂O₇ 
• 68027-40-7 2,4-di-O-trimethylsilylthymine 
• 65-71-4 2,4-dihydroxy-5-methylpyrimidine 
• 271248-28-3 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-L-thymidine 
• 237060-98-9 2',3',5'-tri-O-benzoyl-5-methyl-L-uridine 
• 50571-26-1 5'-DMT-thymidine-3'-H-phosphonate 
• 124314-22-3 1-[(4S,5R)-5-Benzyloxymethyl-4-(2-methanesulfonyl-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 124314-14-3 1-[(4S,5R)-5-Benzyloxymethyl-4-(2-methanesulfinyl-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 124314-23-4 1-((4S,5R)-5-Benzyloxymethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 78138-02-0 1-(3,5-di-O-benzyl-2-deoxy-α,β-D-erythro-pentofuranosyl)thymine 
• 35898-30-7 C₂₄H₂₂N₂O₇ 
• 75-24-1 trimethylaluminum 

Downstream Products

• 116454-12-7 5'-(2,6-dichlorobenzoyl)-deoxythymidine 
• 1333995-40-6 C₂₁H₂₄ClN₈O₆P 
• 1333995-50-8 C₂₁H₂₆N₉O₆P 
• 1333995-78-0 C₂₁H₂₅ClN₉O₆P 
• 1333995-93-9 C₂₁H₂₇N₁₀O₆P 
• 1333996-11-4 C₂₁H₂₇N₆O₈P 
• 132979-39-6 1-(3-azido-2,3-dideoxy-β-L-erythro-pentofuranosyl)thymine 
• 1356470-38-6 5-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)methyl)-2'-deoxy-β-L-uridine 
• 1356470-37-5 3',5'-di-O-acetyl-5-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)methyl)-2'-deoxy-β-L-uridine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 52417-09-1 3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine 
• 99280-64-5 O^3',O^5',3-tris(pentafluorobenzyl)-thymidine 
• 99268-60-7 3',5'-bis(O-pentafluorobenzyl)-3-methylthymidine 
• 99268-61-8 3',5'-bis(O-pentafluorobenzyl)-O⁴-ethylthymidine 

Relevant articles and documents

Facile synthesis of thymidine derivatives by cross-coupling of 5-halogenouridine derivatives with trimethylaluminum

An efficient method for the introduction of a methyl group in the 5-position of uridine derivatives is described. This method involves three steps: protection of 5-halogenouridines 4 and 5 with hexamethyldisilazane, a palladium-catalyzed cross-coupling of the pertrimethylsilylated nucleosides with trimethylaluminum, and subsequent deprotection to afford the corresponding thymidine derivatives 6 in high overall yields.

Synthesis method of beta-thymidine

The invention discloses a synthesis method of beta-thymidine. The synthesis method takes trimethylchlorosilane and 5-methyluracil as raw materials to react; in a reaction line process, tetraacetylribose, trifluoromethanesulfonic acid, N,N-dimethylformamide and acetylchloride are introduced; then hydrogenation reaction and hydrolysis reaction are carried out to finally obtain a beta-thymidine finished product and the yield is 89 percent. Compared with an existing synthesis method, the synthesis method of the beta-thymidine has the advantages that the price of raw materials is low, the content of the beta-thymidine in the final product is high, and pollution to the environment in a production process is small; in a synthesis process, the content of generated impurities is less. According to the synthesis method disclosed by the invention, an obtained result is stable and the operation is simple; demands on equipment and preparation environments are not strict so that large-scale popularization is facilitated.

Method for preparing high-purity telbivudine compound

The invention belongs to the technical field of medicine and provides a method for preparing a high-purity telbivudine compound. The method includes the steps that an LTD-4 compound serves as the raw material and reacts with thymine subjected to silicification protection, and an intermediate, namely an LTD-5 compound, can be obtained; then, through deprotection reaction, the telbivudine compound is obtained after post-processing, wherein MeONa serves as an alkaline reagent of the deprotection reaction, and strong-acidity resin serves as a dealkalization reagent. The method simplifies the production process, the yield of each step is high, and a target product high in purity and yield is obtained. Please see the structural formula in the description.