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137215-27-1

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137215-27-1 Usage

General Description

7-MERCAPTO-4-METHYLCOUMARIN is a chemical compound known for its fluorescent properties, making it useful in various applications such as fluorescence microscopy and imaging. It belongs to the family of coumarin derivatives, which are known for their diverse biological activities. This particular compound has been studied for its potential as a fluorescent probe for cysteine and hydrogen sulfide detection, as well as for its antioxidant and antibacterial properties. Its unique chemical structure and properties make it a promising candidate for further research and potential applications in the fields of chemistry, biology, and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 137215-27-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,1 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 137215-27:
(8*1)+(7*3)+(6*7)+(5*2)+(4*1)+(3*5)+(2*2)+(1*7)=111
111 % 10 = 1
So 137215-27-1 is a valid CAS Registry Number.

137215-27-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methyl-7-sulfanylchromen-2-one

1.2 Other means of identification

Product number -
Other names 7-mercapto-4-methyl-coumarin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137215-27-1 SDS

137215-27-1Downstream Products

137215-27-1Relevant articles and documents

Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2′-monomethyl-4-methyl- and 1′-thia-4-methyl-(3′R, 4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

Xu, Shi-Qing,Yan, Xin,Chen, Ying,Xia, Peng,Qian, Keduo,Yu, Donglei,Xia, Yi,Yang, Zheng-Yu,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung

, p. 7203 - 7211 (2010)

In a continuing investigation into the pharmacophores and structure-activity relationship (SAR) of (3′R,4′R)-3′, 4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) as a potent anti-HIV agent, 2′-monomethyl substituted 1′-oxa, 1′-thia, 1′-sulfoxide, and 1′-sulfone analogs were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Among them, 2′S-monomethyl-4-methyl DCK (5a)? and 2′S-monomethyl-1′-thia-4-methyl DCK (7a) exhibited potent anti-HIV activity with EC50 values of 40.2 and 39.1 nM and remarkable therapeutic indexes of 705 and 1000, respectively, which were better than those of the lead compound DCK in the same assay. In contrast, the corresponding isomeric 2′R-monomethyl-4-methyl DCK (6) and 2′R-monomethyl- 1′-thia-4-methyl DCK (8) showed much weaker inhibitory activity against HIV-1 replication. Therefore, the bioassay results suggest that the spatial orientation of the 2′-methyl group in DCK analogs can have important effects on anti-HIV activity of this compound class.

Design, synthesis and biological evaluation of novel 7-mercaptocoumarin derivatives as α1-adrenoceptor antagonists

Xie, Sai-Sai,Wang, Xiao-Bing,Li, Jiang-Yan,Kong, Ling-Yi

, p. 16 - 24 (2013/02/23)

Study on the pharmacophore model of α1-adrenoceptor (α1-AR) antagonists led to design a series of novel 7-mercaptocoumarin derivatives as α1-AR antagonists. All designed compounds have been synthesized and biologically eva

Synthesis of methyl derivatives of linear and angular thienocoumarins and thiopyranocoumarins

Rodighiero,Pastorini,Chilin,Marotto

, p. 847 - 852 (2007/10/03)

New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7- mercaptocoumarin, which were considered with chloroketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine which methods produced the best yields of the desired thienocoumarins 15, 16, 17, 18, 22, 23, 24, 27 and thiopyranocoumarins 28 and 29.

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