1372532-82-5

Basic information

• Product Name: 2-chloro-N-(2,2-difluoroethyl)furo[3,2-d]pyrimidin-4-amine
• Synonyms: 2-chloro-N-(2,2-difluoroethyl)furo[3,2-d]pyrimidin-4-amine
• CAS NO: 1372532-82-5
• Molecular Weight: 233.605
• Mol File: 1372532-82-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(2,2-difluoroethyl)furo[3,2-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(2,2-difluoroethyl)furo[3,2-d]pyrimidin-4-amine(1372532-82-5)
• EPA Substance Registry System: 2-chloro-N-(2,2-difluoroethyl)furo[3,2-d]pyrimidin-4-amine(1372532-82-5)

Safety Data

• Hazardous Substances Data: 1372532-82-5(Hazardous Substances Data)

Upstream product

• 956034-07-4 2,4-dichloro-furo[3,2-d]pyrimidine 
• 430-67-1 2,2-difluorethylamine 

Relevant articles and documents

Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors

A series of furano[3,2-d]pyrimidine Syk inhibitors were synthesized and optimized for their enzyme potency and selectivity versus other kinases. In addition, ADME properties were assessed and compounds were prepared with optimized profiles for in vivo experiments. Compound 23 was identified as having acceptable pharmacokinetic properties and demonstrated efficacy in a rat collagen induced arthritis model.