137320-21-9

Basic information

• Product Name: 6-<(4-Nitrophenyl)imino>-2,4-dimethylpyrido<1',2':3,4>pyrimido<4,5-d>pyrimidine-1,3(2H,4H)-dione
• CAS NO: 137320-21-9
• Molecular Weight: 378.347
• Mol File: 137320-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-<(4-Nitrophenyl)imino>-2,4-dimethylpyrido<1',2':3,4>pyrimido<4,5-d>pyrimidine-1,3(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-<(4-Nitrophenyl)imino>-2,4-dimethylpyrido<1',2':3,4>pyrimido<4,5-d>pyrimidine-1,3(2H,4H)-dione(137320-21-9)
• EPA Substance Registry System: 6-<(4-Nitrophenyl)imino>-2,4-dimethylpyrido<1',2':3,4>pyrimido<4,5-d>pyrimidine-1,3(2H,4H)-dione(137320-21-9)

Safety Data

• Hazardous Substances Data: 137320-21-9(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 99747-54-3 1,3-dimethyl-2,4-dioxo-6-<(triphenylphosphoranylidene)amino>-1,2,3,4-tetrahydropyrimidine 
• 100-28-7 4-Nitrophenyl isocyanate 

Relevant articles and documents

Reactions of uracils. 21. Zwitterionic heteropolycyclic uracils by a novel three-component reaction: Iminophosphorane, isocyanate, heteroarene

The novel three-component reaction of (uracil-6-ylimino)phosphorane 1, isocyanate 2, and (substituted) pyridines gives, in a one-pot procedure, a variety of new pyrido[1',2':3,4]pyrimido[4,5-d]pyrimidines 3-11. The zwitterionic ground state of these new ring systems is i.a. established by means of solvatochromism, Hammett correlations, NMR, and X-ray analysis. Replacement of the pyridine by isoquinoline and phthalazine gives access to the novel ring systems pyrimido[4',5':4,5]pyrimido[6,1-a]isoquinoline and -phthalazine, which are formed as dihydro derivatives (14, 15) or as zwitterions (13, 17), depending on the reaction conditions. Oxidative cleavage of the phthalazine 15 in nitrobenzene affords the pyrimido[4,5-d]pyrimidines 16.