1373886-20-4Relevant articles and documents
Chitosan: An efficient biodegradable and recyclable green catalyst for one-pot synthesis of 3,4-dihydropyrimidinones of curcumin in aqueous media
Lal, Jaggi,Gupta, Sushil K.,Agarwal, Dau D.
, p. 38 - 43 (2012/10/30)
An efficient procedure for the synthesis of curcumin 3,4- dihydropyrimidinones has been developed by simple one-pot condensation of curcumin, aromatic aldehydes and urea/thiourea in the presence of commercially available chitosan in 2% acetic acid in aqueous media at 60°C for 80-90 min. In the reaction, curcumin: a potential biologically active molecule has been used as a component of multi-component synthesis using chitosan as an efficient biodegradable and recyclable green catalyst. The resultant product curcumin 3,4-dihydropyrimidinone is formed in excellent yield (97%). The chitosan catalyst can be reused for without loss of catalytic activity.