1374003-10-7

Basic information

• Product Name: C₁₆H₁₀F₄N₂O₄
• CAS NO: 1374003-10-7
• Molecular Weight: 370.26
• Mol File: 1374003-10-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₀F₄N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₀F₄N₂O₄(1374003-10-7)
• EPA Substance Registry System: C₁₆H₁₀F₄N₂O₄(1374003-10-7)

Safety Data

• Hazardous Substances Data: 1374003-10-7(Hazardous Substances Data)

Upstream product

• 53072-18-7 2,3,4,5-tetrafluorobenzyl alcohol 
• 100-13-0 4-nitrostyrene 
• 1374003-02-7 2,3,4,5-tetrafluorobenzyl N-tosyloxycarbamate 

Relevant articles and documents

Copper bis(oxazolines) as catalysts for stereoselective aziridination of styrenes with N-tosyloxycarbamates

A Cu(I)-catalyzed asymmetric aziridination of styrenes with a chiral N-tosyloxycarbamate has been developed. Double stereodifferentiation was observed and both the N-tosyloxycarbamate substituent and the bis(oxazoline) ligand have a significant effect on the yields and diastereoselectivities. The best results for the aziridination were obtained with electron-deficient styrenes. Subsequent ring-opening reactions of styrene-derived aziridines at the benzylic position were observed with various oxygen and nitrogen nucleophiles under Lewis acid catalysis affording the corresponding products with complete inversion of stereochemistry. The strategy was used to synthesize the β-blocker, (R)-nifenalol.