1374255-89-6

Basic information

• Product Name: (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide
• Synonyms: (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide
• CAS NO: 1374255-89-6
• Molecular Weight: 291.27
• Mol File: 1374255-89-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide(1374255-89-6)
• EPA Substance Registry System: (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide(1374255-89-6)

Safety Data

• Hazardous Substances Data: 1374255-89-6(Hazardous Substances Data)

Upstream product

• 101999-38-6 (S)-4-benzyloxy-dihydrofuran-2(3H)-one 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 383-63-1 ethyl trifluoroacetate, 
• 1374255-88-5 (S)-4-amino-2-(benzyloxy)butan-1-ol 
• 186429-14-1 (S)-3-benzyloxy-4-hydroxybutanamide 

Downstream Products

• 911313-90-1 (3S)-N(H)-3-(benzyloxy)pyrrolidine 
• 1374255-90-9 (S)-2-benzyloxy-4-(2,2,2-trifluoroacetamido)butyl methanesulfonate 

Relevant articles and documents

Synthesis of chiral five-, six-, and seven-membered heterocycles from (S)-3-hydroxy-γ-butyrolactone

Chiral small molecules such as amino alcohols and their heterocyclic derivatives are useful building blocks for asymmetric synthesis and the preparation of biologically active compounds. Using a common starting material derived from carbohydrate, the (S)-3-hydroxy - butyrolactone, we have synthesized several five-, six-, and seven-membered nitrogen-containing chiral heterocycles. These include (S)-3-benzyloxypyrrolidine, a protected 6-substituted morpholin-3-one and its homologous 1,4-oxazepan-3-one, and 6-trityloxymethyl tetrahydro-1,3-oxazine-2-thiones. These chiral small heterocycles were synthesized from the lactone via efficient cyclization reactions. Their syntheses and characterization are reported here. Georg Thieme Verlag Stuttgart - New York.