137444-51-0

Basic information

• Product Name: (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one
• Synonyms: (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one
• CAS NO: 137444-51-0
• Molecular Formula: C₁₄H₁₂O₂S
• Molecular Weight: 244.30888
• Mol File: 137444-51-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one(137444-51-0)
• EPA Substance Registry System: (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one(137444-51-0)

Safety Data

• Hazardous Substances Data: 137444-51-0(Hazardous Substances Data)

Usage

General Description

(2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, also known as 2E-Methyl-3-(4-methoxyphenyl)-2-propen-1-one, is a chemical compound with the molecular formula C13H12O2S. It is a yellow to brown solid with a sweet, floral, and fruity odor. (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one is used in the synthesis of pharmaceuticals and as an intermediate in organic synthesis. It is also used as a flavoring agent in the food industry and as a fragrance ingredient in the perfumery industry. Additionally, it has potential applications in the field of medicine and cosmetics due to its biological activities and therapeutic properties.

Upstream product

• 6165-68-0 thiophene boronic acid 
• 201230-82-2 carbon monoxide 
• 136618-41-2 E-2'-p-methoxystyryl iodide 
• 88-15-3 2-Acetylthiophene 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 74007-50-4 3,3-Dimethoxy-2-(4-methoxy-phenyl)-1-thiophen-2-yl-propan-1-one 
• 18213-38-2 5-(4-methoxy-phenyl)-1-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 136786-89-5 5-(4-Methoxy-phenyl)-1-methyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 136786-72-6 5-(4-Methoxy-phenyl)-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 128342-41-6 4-(4-methoxyphenyl)-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 956130-61-3 4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyridine-2(1H)-thione 

Relevant articles and documents

Stereoselective multicomponent synthesis of [3-(5-substituted 2-methoxyphenyl)-5-aryl-2-phenyltetrahydro-4-isoxazolyl](2-thienyl)methanones via 1,3-dipolar cycloaddition

Three-component stereoselective synthesis of a set of new tetra substituted isoxazolidines from 5-substituted 2-methoxybenzaldehydes, N-phenylhydroxylamine and 1-(2-thienyl)-3-arylprop-2-en-1-ones has been achieved. The effect of microwave irradiation on the reaction under solvent-free conditions has also been investigated. The stereochemistry of the final products has been confirmed by NMR and single crystal X-ray analysis.

Synthesis, crystal structure, spectroscopic analysis and computational study of (Z)-1-(2,4-dinitrophenyl)-2-((E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) allylidene) hydrazine by DFT and AIM approach

Abstract The title compound was synthesized and characterized by IR, 1H NMR, 13C NMR and single crystal X-ray diffraction studies. Quantum chemical calculations have been performed at DFT level of theory using B3LYP functional and 6-

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activit

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.