137530-41-7

Basic information

• Product Name: Aids005680
• Synonyms: (+)-(2S,5R)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine;(+)-2'-Deoxy-5-flouro-3'-thiacytidine;2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-;5Fc-(+).B.;Aids005680;Aids-005680;oxathiolan;4-AMino-5-fluoro-1-[(2S,5R)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]- 2(1H)-pyriMidinone
• CAS NO: 137530-41-7
• Molecular Formula: C8H10FN3O3S
• Molecular Weight: 247.2467032
• Product Categories: Carbohydrates & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 137530-41-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.82±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 13.83±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Aids005680(CAS DataBase Reference)
• NIST Chemistry Reference: Aids005680(137530-41-7)
• EPA Substance Registry System: Aids005680(137530-41-7)

Safety Data

• Hazardous Substances Data: 137530-41-7(Hazardous Substances Data)

Usage

Description

Aids005680, also known as ent-EMtricitabine, is a reverse transcriptase inhibitor and a nucleoside analog structurally related to Lamivudine (L172500). It is a white to off-white solid and has been found to be an effective antiviral agent against various viruses, including HIV and HBV.

Uses

Used in Antiviral Applications:
Aids005680 is used as a reverse transcriptase inhibitor for its effectiveness against HIV, HBV, and other viruses that replicate in a similar manner. It helps in inhibiting the replication of these viruses, thus providing a potential treatment option for patients suffering from these viral infections.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Aids005680 is used as an active pharmaceutical ingredient for the development of antiviral drugs. Its potent antiviral properties make it a valuable compound in the fight against HIV, HBV, and other related viruses.
Used in Research and Development:
Aids005680 is also utilized in research and development for the study of viral replication mechanisms and the development of new antiviral therapies. Its structural similarity to Lamivudine (L172500) allows researchers to explore its potential in combination therapies and to better understand the mechanisms of action of reverse transcriptase inhibitors.

Upstream product

• 149819-36-3 (+)-(2S,5R)-5-fluoro-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N₄-benzoylcytosine 
• 144371-00-6 (+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine 

Relevant articles and documents

Preparation method for emtricitabine isomer

The invention discloses a preparation method for an embritabine isomer. The preparation method comprises the following steps: with Solketal as a starting material, allowing the Solketal to undergo a six-step reaction of esterification, hydrolysis, oxidation, condensation cyclization, acetylation and glycosylation condensation so as to synthesize four mixture intermediates of emtricitabine; and splitting the four isomer intermediates into a cis-isomer mixture and a trans-isomer mixture through a chiral reagent. According to the invention, by adoption of a simple starting material, a mixture forsplitting key intermediates of four optical isomers of the emtricitabine is synthesized through the six-step reaction, and chiral acid is utilized to split the four isomers into a mixture of cis andtrans isomers, so the preparation method provided by the invention has the advantages of simple and convenient operation, high yield and high isomer chiral purity.

Processes for the diastereoselective synthesis of nucleoside analogues

The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.