1375477-29-4

Basic information

• Product Name: cataCXium A-Pd-G2
• Synonyms: cataCXium A-Pd-G2;Chloro[(di(1-adamantyl)-N-butylphosphine)-2-(2-aminobiphenyl)]palladium(II);cataCXium(R) A Pd G2;[2'-(Amino)[1,1'-biphenyl]-2-yl][butylbis(tricyclo[3.3.1.1(3,7)]dec-1-yl)phosphine]chloropalladium
• CAS NO: 1375477-29-4
• Molecular Formula: C36H49ClNPPd
• Molecular Weight: 668.64
• Mol File: 1375477-29-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 220°C (decomposition)
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: cataCXium A-Pd-G2(CAS DataBase Reference)
• NIST Chemistry Reference: cataCXium A-Pd-G2(1375477-29-4)
• EPA Substance Registry System: cataCXium A-Pd-G2(1375477-29-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1375477-29-4(Hazardous Substances Data)

Usage

Description

cataCXium A-Pd-G2 is a second-generation catalyst developed by Buchwald, which is utilized in the field of organic chemistry. It is specifically designed to serve as a palladium source for the coupling of potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides. This process is carried out through the Suzuki-Miyaura reaction, which results in the formation of protected secondary alcohols.

Uses

Used in Pharmaceutical Industry:
cataCXium A-Pd-G2 is used as a catalyst for the Suzuki-Miyaura reaction to produce protected secondary alcohols. These alcohols are essential in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapies.
Used in Chemical Research and Development:
In the field of chemical research and development, cataCXium A-Pd-G2 is employed as a catalyst for the Suzuki-Miyaura reaction. This reaction is crucial for the synthesis of complex organic molecules, which can be used in various applications, including the creation of new materials, dyes, and other specialty chemicals.
Used in Material Science:
cataCXium A-Pd-G2 is also used in material science as a catalyst for the Suzuki-Miyaura reaction. The protected secondary alcohols produced through this process can be utilized in the development of advanced materials with specific properties, such as improved strength, durability, or conductivity.
Overall, cataCXium A-Pd-G2 plays a significant role in various industries, including pharmaceuticals, chemical research and development, and material science, by enabling the efficient synthesis of protected secondary alcohols through the Suzuki-Miyaura reaction.

Upstream product

• 847616-85-7 di-μ-chlorobis[2'-(amino-N)[1,1'-biphenyl]-2-yl-C]dipalladium(II) 
• 321921-71-5 catacxium A 

Relevant articles and documents

Stereospecific cross-coupling of secondary organotrifluoroborates: Potassium 1-(benzyloxy)alkyltrifluoroborates

Potassium 1-(alkoxy/acyloxy)alkyltrifluoroborates have been synthesized through a copper-catalyzed diboration of aldehydes and subsequent conversion of the resulting potassium 1-(hydroxy)alkyltrifluoroborates. The palladium-catalyzed Suzuki-Miyaura reaction employing the potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides provides access to protected secondary alcohols in high yields. The β-hydride elimination pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the diorganopalladium intermediate by coordination of the arene to the metal center. This cross-coupling is stereospecific with complete retention of stereochemistry.