1375548-30-3Relevant articles and documents
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Curtin, Michael L.,Heyman, H. Robin,Clark, Richard F.,Sorensen, Bryan K.,Doherty, George A.,Hansen, T. Matthew,Frey, Robin R.,Sarris, Kathy A.,Aguirre, Ana L.,Shrestha, Anurupa,Tu, Noah,Woller, Kevin,Pliushchev, Marina A.,Sweis, Ramzi F.,Cheng, Min,Wilsbacher, Julie L.,Kovar, Peter J.,Guo, Jun,Cheng, Dong,Longenecker, Kenton L.,Raich, Diana,Korepanova, Alla V.,Soni, Nirupama B.,Algire, Mikkel A.,Richardson, Paul L.,Marin, Violeta L.,Badagnani, Ilaria,Vasudevan, Anil,Buchanan, F. Greg,Maag, David,Chiang, Gary G.,Tse, Chris,Michaelides, Michael R.
, p. 3317 - 3325 (2017/07/07)
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal functiona
