137766-76-8

Basic information

• Product Name: (R)-2-Phenylpiperazine
• CAS NO: 137766-76-8
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.235
• Mol File: 137766-76-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 169 °C
• Density: 0.997g/cm³
• CAS DataBase Reference: (R)-2-Phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Phenylpiperazine(137766-76-8)
• EPA Substance Registry System: (R)-2-Phenylpiperazine(137766-76-8)

Safety Data

• Hazardous Substances Data: 137766-76-8(Hazardous Substances Data)

Usage

General Description

(R)-2-Phenylpiperazine, also known as 2-(1-piperazinyl)ethylbenzene, is a chemical compound with the molecular formula C10H15N. It is a piperazine derivative and is commonly used as a building block in the synthesis of various pharmaceutical drugs. Its structure contains a piperazine ring with a phenyl group attached, and it is classified as a psychoactive agent that may have anxiolytic and antidepressant effects. (R)-2-Phenylpiperazine has also been investigated for its potential use in the treatment of schizophrenia and other psychiatric disorders. Additionally, it has been studied for its affinity to serotonin and dopamine receptors, which suggests its possible role as a neurotransmitter modulator. Overall, (R)-2-Phenylpiperazine is a significant compound in drug development and has potential therapeutic applications.

Upstream product

• 108-95-2 phenol 
• 131543-46-9 Glyoxal 
• 62779-69-5 (R)-1,2-Diamino-1-phenylethane 
• 1074-12-0 phenylglyoxal hydrate 
• 107-15-3 ethylenediamine 
• 81554-02-1 (R)-3-phenylpiperazine-2,5-dione 

Downstream Products

• 1042984-13-3 C₂₁H₂₁N₅O 

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

Benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them

New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R1 is a hydrogen atom or a hydroxyl or alkyl radical, R2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R3 is a heterocyclic radical, and R4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them. These new products are useful as antimicrobials, or in the treatment of AIDS. STR1