1377848-08-2

Basic information

• Product Name: (R)-6-(4-bromophenyl)-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-2H-pyran-2-one
• CAS NO: 1377848-08-2
• Molecular Weight: 397.191
• Mol File: 1377848-08-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-6-(4-bromophenyl)-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-(4-bromophenyl)-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-2H-pyran-2-one(1377848-08-2)
• EPA Substance Registry System: (R)-6-(4-bromophenyl)-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-2H-pyran-2-one(1377848-08-2)

Safety Data

• Hazardous Substances Data: 1377848-08-2(Hazardous Substances Data)

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 1196-67-4 3-phenyl-2-butenal 
• 98-86-2 acetophenone 
• 54976-37-3 3-phenylbut-2-en-1-ol 
• 1504-72-9 ethyl 3-phenylbut-2-enoate 

Relevant articles and documents

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes

Cooperative catalysis combining a transition metal with an N-heterocyclic carbene is challenging due to strong binding of NHCs towards late transition metals. We report the first example of synergistic catalysis by a chiral NHC and a coordinatively unsaturated ruthenium compound. RuCl3 was found to mediate efficient aerobic oxidation of homoenolates generated from enals and the N-heterocyclic carbene. The resulting α,β-unsaturated acylazolium intermediate reacts selectively with 1,3-dicarbonyl compounds or ketones at either the β- or γ-carbon, yielding polysubstituted chiral lactones in high yield and with excellent enantioselectivity (up to 98 % yield, 94 % ee). This protocol can be applied to structurally sophisticated substrates.