137864-22-3

Basic information

• Product Name: Valesteramide
• Synonyms: N-[2'-cyano-biphenyl-4-yl methyl]-N-valeryl-(L)-valine benzyl ester
• CAS NO: 137864-22-3
• Molecular Formula: C₃₁H₃₄N₂O₃
• Molecular Weight: 482.623
• Mol File: 137864-22-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 657.065 °C at 760 mmHg
• Flash Point: 351.181 °C
• Density: 1.147 g/cm³
• CAS DataBase Reference: Valesteramide(CAS DataBase Reference)
• NIST Chemistry Reference: Valesteramide(137864-22-3)
• EPA Substance Registry System: Valesteramide(137864-22-3)

Safety Data

• Hazardous Substances Data: 137864-22-3(Hazardous Substances Data)

Usage

General Description

Valesteramide is a chemical compound commonly used as an antifungal agent in agriculture and horticulture. It is a broad-spectrum fungicide, meaning it is effective against a wide range of fungal pathogens. Valesteramide works by inhibiting the growth and reproduction of fungi, ultimately preventing plant diseases such as powdery mildew, rust, and leaf spots. It is often formulated as a liquid or powder for easy application and is commonly used on a variety of crops, including fruits, vegetables, and ornamental plants. Due to its effectiveness and relatively low toxicity to humans and other non-target organisms, valesteramide is a popular choice for controlling fungal diseases in the agricultural and horticultural industries.

Upstream product

• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 21760-98-5 L-valine benzyl ester 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 638-29-9 n-valeryl chloride 
• 137864-23-4 (S)-N-[(2'-Cyano-biphenyl-4-yl)methyl]valine benzyl ester 

Downstream Products

• 137863-20-8 (S)-N-(1-benzyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine 
• 137863-90-2 methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 1298055-65-8 C₁₂H₂₃N*C₂₄H₂₈N₂O₃ 
• 1298055-61-4 C₃₃H₃₆N₂O₃ 
• 443093-86-5 N-((2'-(cyano)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valine 

Relevant articles and documents

Synthesis of 5-Substituted 1 H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles is described. The process involves the reaction between a polymer-supported triorganotin azide and organic nitriles. The polymer-supported organotin azide, which is in situ generated with a polystyrene-supported triorganotin alkoxide and trimethylsilylazide, is immobilized in a packed bed reactor. This approach is simple, fast (it takes from 7.5 to 15 min), and guarantees a low concentration of tin residues in the products (5 ppm). The process was developed to aryl-, heteroaryl-, and also alkylnitriles and was applied for the synthesis of valsartan, an angiotensin II receptor antagonist.

PROCESS FOR PREPARATION OF VALSARTAN INTERMEDIATE

The present invention provides a process for preparation of a key intermediate of valsartan in a pure form and use of this intermediate for the preparation of valsartan or a pharmaceutically acceptable salt in pure form.

Process for the preparation of valsartan and its intermediates

The present invention relates to an improved process for the preparation of valsartan and its intermediates in substantially pure enantiomeric form. In particular, the present invention provides a process for preparing benzyl valsartan intermediate substantially free of organotin impurities. The valsartan produced from such benzyl valsartan intermediate requires significantly lower catalyst loading and has superior purity.