1378834-52-6

Basic information

• Product Name: 2-chloro-4-phenylbutyraldehyde
• Synonyms: 2-chloro-4-phenylbutyraldehyde
• CAS NO: 1378834-52-6
• Molecular Weight: 182.65
• Mol File: 1378834-52-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-phenylbutyraldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-phenylbutyraldehyde(1378834-52-6)
• EPA Substance Registry System: 2-chloro-4-phenylbutyraldehyde(1378834-52-6)

Safety Data

• Hazardous Substances Data: 1378834-52-6(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 18328-11-5 3-benzyl propionaldehyde 

Downstream Products

• 58039-64-8 2-[2-phenylethyl]-morpholine 
• 167273-43-0 MCO-III-157-Rac 
• 58040-19-0 4-benzyl-2-phenethylmorpholine 
• 141916-53-2 2-chloro-4-phenylbutan-1-ol 
• 1403749-43-8 (R)-ethyl 2-fluoro-4-phenylbutanoate 

Relevant articles and documents

N-Heterocyclic Carbene-Catalyzed Synthesis of α-Trifluoromethyl Esters

The N-heterocyclic carbene (NHC)-catalyzed trifluoromethylation of α-chloro aldehydes was developed, allowing straightforward access to valuable α-trifluoromethyl ester derivatives. The unique combination of an electrophilic trifluoromethylation reagent with NHC catalysis was the key for the functionalization of a broad range of α-chloro aldehydes, and the products are formed in moderate to good yields. Investigations of the enantioselective version of this reaction afforded the enantioenriched products in moderate yields with good ee values.

Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines

Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted carbonyl derivatives. Herein, we demonstrate that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to yield highly valuable trans-cyclopropylamines in good yields and high diastereoselectivities. GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this strategy.

A general, enantioselective synthesis of protected morpholines and piperazines

A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N′-protected piperazines from a common intermediate.