1378872-36-6 Usage
Description
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide is a complex organic compound characterized by its unique molecular structure, which features a trichlorophenoxyacetic acid backbone with a pyrrol-2-ylmethylene hydrazide moiety. (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide exhibits a diverse range of biological activities and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide is used as a pharmaceutical agent for its potential anticancer properties. It has been found to selectively inhibit breast cancer stem cells with greater than 23-fold selectivity, making it a promising candidate for the development of targeted cancer therapies.
Used in Research Applications:
In the field of research, (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide serves as a valuable tool for studying the molecular mechanisms underlying cancer progression and the development of resistance to conventional treatments. Its ability to alter the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways provides insights into the complex interplay of signaling networks in cancer cells.
Used in Drug Development:
The compound's stability in saline and modest stability in human plasma make it a suitable candidate for further drug development. Researchers can leverage its unique properties to design novel therapeutic strategies and improve the efficacy of existing treatments for various types of cancer, including breast carcinoma.
References
1) Carmody et al. (2012), Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells; J. Biomol. Screening, 17 1204
2) Germain et al. (2012), Identification of a selective small molecule inhibitor of breast cancer stem cells; Bioorg. Med. Chem., 22 3571
3) Rees et al. (2015), Correlating chemical sensitivity and basal gene expression reveals mechanism of action; Nat. Chem. Biol. 12 109
Check Digit Verification of cas no
The CAS Registry Mumber 1378872-36-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,8,8,7 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1378872-36:
(9*1)+(8*3)+(7*7)+(6*8)+(5*8)+(4*7)+(3*2)+(2*3)+(1*6)=216
216 % 10 = 6
So 1378872-36-6 is a valid CAS Registry Number.
1378872-36-6Relevant articles and documents
COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER STEM CELLS
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Page/Page column 52, (2013/03/28)
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: Formula (I).
