137890-05-2

Basic information

• Product Name: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)
• Synonyms: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI);5-Acetyl-1-methylpyrazole;1-(1-Methyl-1H-pyrazol-5-yl)
• CAS NO: 137890-05-2
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14052
• Product Categories: ACETYLGROUP
• Mol File: 137890-05-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 221 °C at 760 mmHg
• Flash Point: 87.4 °C
• Appearance: light yellow to dark yellow liquid
• Density: 1.11 g/cm³
• Vapor Pressure: 0.11mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(137890-05-2)
• EPA Substance Registry System: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(137890-05-2)

Safety Data

• Hazardous Substances Data: 137890-05-2(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI) is a chemical compound with the molecular formula C7H8N2O. It is also known by its systematic name, 1-(1-methyl-1H-pyrazol-5-yl)ethanone. Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI) is a ketone derivative and belongs to the class of organic compounds known as pyrazoles, which are heterocyclic compounds containing a five-membered ring with two nitrogen atoms and three carbon atoms. Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI) may have various industrial applications, including its use as a building block in the synthesis of other organic compounds. Its specific properties and potential uses depend on its chemical structure and the reactions it can participate in.

InChI:InChI=1/C6H8N2O/c1-5(9)6-3-4-7-8(6)2/h3-4H,1-2H3

Upstream product

• 1339452-16-2 N-methoxy-N-methyl-2-methyl-2H-pyrazole-3-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 20583-33-9 1-(1H-pyrazol-5-yl)ethanone 
• 74-88-4 methyl iodide 
• 66121-72-0 1-Methylpyrazole-5-carboxylic acid nitrile 
• 84547-59-1 2-methyl-2H-pyrazole-3-carbonyl chloride 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 1616100-88-9 (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(1-methyl-1H-pyrazol-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide 
• 1616100-90-3 N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(1-methyl-1H-pyrazol-5-yl)butan-2-yl)carbamothioyl)benzamide 
• 1616100-87-8 (R)-N-((S)-2-(2,4-difluorophenyl)-4-(1-methyl-1H-pyrazol-5-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

NITRATION OF ACETYL DERIVATIVES OF 1-METHYLPYRAZOLE

The nitration of acetyl-substituted 1-methylpyrazoles with nitric acid in 20percent oleum and in acetic anhydride was studied.Dipyrazolofuroxans are formed in the case of nitration in oleum. 4-Nitro-3-acetyl-1-methylpyrazole was obtained by nitration of 3-acetyl-1-methylpyrazole in acetic anhydride.

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n = 0 or 1 and R2 is a methyl group when n = 0 and a hydrogen atom when n = 1. Process for the preparation thereof and therapeutic use thereof.