1379342-51-4 Usage
Description
3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol is a chemical compound with a unique molecular structure that features a cyclopenta[b]pyridine ring system and a bromo substituent. It is known for its potential applications in various fields, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol is used as a reagent for the preparation of oral p300/CBP histone acetyltransferase inhibitors. These inhibitors play a crucial role in cancer therapy, as they target specific enzymes involved in the regulation of gene expression, thereby affecting the growth and progression of cancer cells.
In Cancer Therapy:
3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol is used as a key component in the development of histone acetyltransferase inhibitors for cancer treatment. These inhibitors help modulate the activity of p300/CBP enzymes, which are known to be involved in the regulation of gene expression and are often dysregulated in cancer cells. By targeting these enzymes, the compound can potentially contribute to the suppression of tumor growth and the improvement of cancer treatment outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1379342-51-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,9,3,4 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1379342-51:
(9*1)+(8*3)+(7*7)+(6*9)+(5*3)+(4*4)+(3*2)+(2*5)+(1*1)=184
184 % 10 = 4
So 1379342-51-4 is a valid CAS Registry Number.
1379342-51-4Relevant articles and documents
HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF
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, (2021/02/25)
The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.
DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS
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, (2019/08/08)
Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt, thereof for use in methods of treatment heart diseases through cardiac sarcomere inhibtion.
ANTIDIABETIC BICYCLIC COMPOUNDS
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Page/Page column 70, (2015/06/18)
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-co
