1380497-61-9

Basic information

• Product Name: CF₃(Ph)CClCHO
• Synonyms: CF₃(Ph)CClCHO
• CAS NO: 1380497-61-9
• Molecular Weight: 222.594
• Mol File: 1380497-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: CF₃(Ph)CClCHO(CAS DataBase Reference)
• NIST Chemistry Reference: CF₃(Ph)CClCHO(1380497-61-9)
• EPA Substance Registry System: CF₃(Ph)CClCHO(1380497-61-9)

Safety Data

• Hazardous Substances Data: 1380497-61-9(Hazardous Substances Data)

Upstream product

• 78659-23-1 3,3,3-trifluoro-2-phenylpropionaldehyde 

Relevant articles and documents

Chemoselective halogenation of 2-hydroperfluoroalkyl aldehydes

2-Hydroaldehydes, RfCH(R)CHO, where Rf = CF 3, C2F5, n-C3F7 and R = CF3, C2F5, n-C3F7, Ph, H, were prepared via acid hydrolysis of the corresponding vinyl ethers, R fC(R) = CHOCH3, which can be readily prepared by reaction of Ph3P+C?HOCH3 with the corresponding ketone. The 2-hydroaldehydes can be chemoselectively converted to the acyl halide, RfCH(R)C(O)X (X = Cl, Br), via free-radical halogenation. The perfluoroalkyl group deactivates the 2-position toward radical abstraction of the 2-hydrogen, and halogenation occurs exclusively at the formyl hydrogen. However, halogenations of the 2-hydroaldehydes in glacial acetic acid chemoselectively gives the 2-haloaldehydes, RfCX(R)CHO, X = Cl, Br. Hydrolysis of the 2-hydroperfluoroacyl halides provides a useful route to 2-hydroperfluoroalkyl branched carboxylic acids, useful ketene precursors. This route avoids the use of toxic fluoroolefins, such as perfluoroisobutylene.