1381861-91-1

Basic information

• Product Name: Bromo-PEG2-t-butyl ester
• Synonyms: Bromo-PEG2-t-butyl ester;Bromo-PEG3-t-butyl ester;tert-Butyl 3-(2-(2-bromoethoxy)ethoxy)propanoate;Br-PEG2-t-butyl ester;Br-PEG2-CH2CH2COOtBu
• CAS NO: 1381861-91-1
• Molecular Formula: C11H21BrO4
• Molecular Weight: 297.18604
• Mol File: 1381861-91-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 332.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.240±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Bromo-PEG2-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Bromo-PEG2-t-butyl ester(1381861-91-1)
• EPA Substance Registry System: Bromo-PEG2-t-butyl ester(1381861-91-1)

Safety Data

• Hazardous Substances Data: 1381861-91-1(Hazardous Substances Data)

Usage

Description

Bromo-PEG2-t-butyl ester is a PEG (polyethylene glycol) linker that features a bromide group and a t-butyl protected carboxyl group. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic PEG spacer. The bromide (Br) acts as an excellent leaving group for nucleophilic substitution reactions, while the t-butyl protected carboxyl group can be deprotected under acidic conditions, making it a versatile compound for various applications.

Uses

Used in Bioconjugation and Drug Synthesis:
Bromo-PEG2-t-butyl ester is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The bromide group facilitates nucleophilic substitution reactions, allowing for the efficient coupling of biomolecules such as proteins, peptides, or nucleic acids. This property is particularly useful in the development of targeted drug delivery systems and the creation of biocompatible materials.
Used in Chemical Synthesis:
In the field of chemical synthesis, Bromo-PEG2-t-butyl ester serves as a versatile building block for the creation of complex molecules. The t-butyl protected carboxyl group can be selectively deprotected under acidic conditions, enabling the introduction of various functional groups and the synthesis of diverse chemical entities.
Used in Pharmaceutical Industry:
Bromo-PEG2-t-butyl ester is used as a pharmaceutical intermediate for the development of novel drugs. The hydrophilic PEG spacer and the reactivity of the bromide group make it an attractive candidate for the design of drugs with improved solubility, bioavailability, and reduced immunogenicity.
Used in Material Science:
In material science, Bromo-PEG2-t-butyl ester is used as a component in the synthesis of hydrogels, polymers, and other biomaterials. The hydrophilic nature of the PEG spacer and the reactivity of the bromide group allow for the creation of materials with tailored properties, such as controlled release systems, tissue engineering scaffolds, and drug delivery devices.
Used in Diagnostics:
Bromo-PEG2-t-butyl ester can be employed as a diagnostic tool in the development of imaging agents and sensors. The reactivity of the bromide group and the hydrophilic PEG spacer can be exploited to attach contrast agents or sensing moieties to biomolecules, enabling the detection and monitoring of various biological processes and diseases.