138199-71-0

Basic information

• Product Name: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)
• Synonyms: levofloxacin hydrate;LEVOFLOXACIN HCL;(s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1);LEVOFLOXACINH HYDROCHLORIDE;(S)-(-)-Ofloxacine;Levofloxacine;(-)-(s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride;Levofloxacin (200 mg)
• CAS NO: 138199-71-0
• Molecular Formula: 2C₁₈H₂₀FN₃O₄*H₂O
• Molecular Weight: 397.83
• EINECS: 1806241-263-5
• Product Categories: Chiral Reagents;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;TEQUIN
• Mol File: 138199-71-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 214-216°C
• Boiling Point: 571.5 °C at 760 mmHg
• Flash Point: 299.4 °C
• Appearance: pale yellow solid
• Density: 1.48 g/cm³
• Vapor Pressure: 6.7E-14mmHg at 25°C
• Storage Temp.: -20°C Freezer
• Solubility: Aqueous Base (Slightly), DMSO (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)(138199-71-0)
• EPA Substance Registry System: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)(138199-71-0)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 24/25-61-60
• WGK Germany: 3
• Hazardous Substances Data: 138199-71-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 138199-71-0 differently. You can refer to the following data:
1. antibacterial
2. Levofloxacin heMihydrate is an antibiotic used against gram-negative organisms.
3. Levofloxacin Hemihydrate is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.

Brand name

Iquix (Sanofi Winthrop); Levaquin (Ortho-McNeil); Quixin (Sanofi Winthrop).

InChI:InChI=1/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1

Upstream product

• 109-01-3 1-methyl-piperazine 
• 100986-89-8 levofloxacin Q-acid 
• 177472-30-9 C₂₀H₂₄FN₃O₄ 

Relevant articles and documents

PROCESS FOR OBTAINING LEVOFLOXACIN FREE FROM SALTS

This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C1-C4)alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts. One characteristic of the process described is that no extractions are necessary in the final step of the process.

Methods for the purification of levofloxacin

Levofloxacin has been purified by dissolving levofloxacin in a polar solvent at an elevated temperature and crystallizing purified levofloxacin. Preferably, an antioxidant is added to increase the purity.