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1382481-80-2

1382481-80-2

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1382481-80-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1382481-80-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,2,4,8 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1382481-80:
(9*1)+(8*3)+(7*8)+(6*2)+(5*4)+(4*8)+(3*1)+(2*8)+(1*0)=172
172 % 10 = 2
So 1382481-80-2 is a valid CAS Registry Number.

1382481-80-2Downstream Products

1382481-80-2Relevant articles and documents

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu 5 PAM

Sheffler, Douglas J.,Wenthur, Cody J.,Bruner, Joshua A.,Carrington, Sheridan J.S.,Vinson, Paige N.,Gogi, Kiran K.,Blobaum, Anna L.,Morrison, Ryan D.,Vamos, Mitchell,Cosford, Nicholas D.P.,Stauffer, Shaun R.,Scott Daniels,Niswender, Colleen M.,Jeffrey Conn,Lindsley, Craig W.

, p. 3921 - 3925 (2012/07/14)

Herein we report the discovery and SAR of a novel metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) with 15-fold selectivity versus mGlu2. The mGlu3 NAM was discovered via a 'molecular switch' from a closely related, potent mGlu5 positive allosteric modulator (PAM), VU0092273. This NAM (VU0463597, ML289) displays an IC 50 value of 0.66 μM and is inactive against mGlu5.

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