138277-78-8

Basic information

• Product Name: ALNESPIRONE
• Synonyms: 8-(4-((5-methoxychroman-3-yl)(propyl)amino)butyl)-8-azaspiro[4.5]decane-7,9-dione
• CAS NO: 138277-78-8
• Molecular Formula: C26H38N2O4
• Molecular Weight: 442.596
• Mol File: 138277-78-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ALNESPIRONE(CAS DataBase Reference)
• NIST Chemistry Reference: ALNESPIRONE(138277-78-8)
• EPA Substance Registry System: ALNESPIRONE(138277-78-8)

Safety Data

• Hazardous Substances Data: 138277-78-8(Hazardous Substances Data)

Upstream product

• 107-08-4 1-iodo-propane 
• 138277-77-7 8-<4-butyl>-8-azaspiro<4.5>decane-7,9-dione 
• 80827-62-9 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione 
• 109140-20-7 5-methoxy-3,4-dihydro-2H-1-benzopyran-3-one 
• 1075-89-4 tetramethylene glutarimide 

Related news

ArticlesA Comparison of the Oxytocin and Vasopressin Responses to the 5-HT1A Agonist and Potential Anxiolytic Drug ALNESPIRONE (cas 138277-78-8) (S-20499)08/24/2019

VAN DE KAR, L. D., A. D. LEVY, Q. LI AND M. S. BROWNFIELD. A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499). PHARMACOL BIOCHEM BEHAV 60(3) 677–683, 1998.—The effect of the serotonin1A (5-HT1A) agonist alnespirone (...detailed

Similar pharmacological properties of 8-OH-DPAT and ALNESPIRONE (cas 138277-78-8) (S 20499) at dopamine receptors: comparison with buspirone08/23/2019

Alnespirone (S 20499) has previously been described as a potential anxiolytic drug that acts by stimulation of 5-HT1A receptors. Some data suggest that alnespirone might also be a weak dopamine D2 receptor agonist: it displays moderate affinity for dopamine D2 receptors in vitro and it inhibits ...detailed

Is the potent 5-HT1A receptor agonist, ALNESPIRONE (cas 138277-78-8) (S-20499), affecting dopaminergic systems in the rat brain?08/22/2019

The effects of the new methoxy-chroman 5-HT1A receptor agonist, alnespirone (S-20499), on the dopamine systems in the rat brain were assessed in vivo by means of electrophysiological and neurochemical techniques. Cumulative doses of alnespirone (0.032–4.1 mg kg−1, i.v.) did not modify the spont...detailed

Short communicationAntidepressant-like effects of ALNESPIRONE (cas 138277-78-8) (S 20499) in the learned helplessness test in rats08/19/2019

The effects of the new chroman derivative, alnespirone (S 20499), which is a selective 5-HT1A receptor agonist, were investigated in an animal model of depression, the learned helplessness test. Rats previously submitted to a session of 60 inescapable electric foot shocks (learned helpless contr...detailed

In vivo comparison of two 5-HT1A receptors agonists ALNESPIRONE (cas 138277-78-8) (S-20499) and buspirone on locus coeruleus neuronal activity08/18/2019

The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the α2-adrenergic properties of the selective 5-HT1A receptor agonist, alnespirone (S-20499), with those of buspirone, a 5-HT1A receptor agonist exhibiting potent α2-adrenoceptor antagonist properties via its p...detailed

Relevant articles and documents

3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis and Structure-Activity Relationship Studies

A series of 3,4-dihydro-3-amino-2H-1-benzopyran derivatives were prepared in order to determine the necessary structural requirements for good affinity for 5-HT1A receptors and high selectivity versus other receptors.Modifications of the extrac