1383428-49-6Relevant articles and documents
Transition metal-free stereoselective α-vinylation of cyclic ketones with arylacetylenes in the superbasic catalytic triad potassium hydroxide/tert-butyl alcohol/dimethyl sulfoxide
Trofimov, Boris A.,Schmidt, Elena Yu.,Zorina, Nadezhda V.,Ivanova, Elena V.,Ushakov, Igor A.,Mikhaleva, Al'Bina I.
supporting information; experimental part, p. 1813 - 1818 (2012/08/13)
A stereoselective α-vinylation of cycloaliphatic ketones with arylacetylenes under the transition metal-free conditions has been developed. The reaction is promoted by the superbasic catalytic triad potassium hydroxide/tert-butyl alcohol/dimethyl sulfoxide (80-110 °C, 1-2 h) to afford mainly (E)-β,γ-ethylenic ketones, their (E)-α,β-isomers being minor products, in up to 83% total yield. Copyright
