138377-66-9 Usage
General Description
HC Yellow No. 15 is a synthetic organic dye commonly used in the textile industry to color various materials, such as fabrics and yarn. This chemical compound belongs to the class of azo dyes, which are characterized by a specific chemical structure containing one or more nitrogen atoms connected by double bonds. HC Yellow No. 15 is known for its vibrant yellow hues and high color fastness properties, making it a popular choice for achieving bright and long-lasting coloration in textiles. However,
Check Digit Verification of cas no
The CAS Registry Mumber 138377-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,3,7 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 138377-66:
(8*1)+(7*3)+(6*8)+(5*3)+(4*7)+(3*7)+(2*6)+(1*6)=159
159 % 10 = 9
So 138377-66-9 is a valid CAS Registry Number.
138377-66-9Relevant articles and documents
Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability
Kim, Hyungmi,Kim, Mi Kyoung,Choo, Hyunah,Chong, Youhoon
supporting information, p. 3213 - 3215 (2016/07/12)
The previously identified Janus kinase 1 (JAK1)-selective inhibitor, 1-(2-aminoethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide (2), suffered from low cell permeability, which resulted in poor pharmacokinetic properties. In this study, by introducing less polar hydrogen bond donors at N1(a hydroxyalkyl or a methylaminoalkyl group) and C2 (a cyclohexanol group) positions, a series of novel benzimidazole derivatives were prepared, which exhibited selective JAK1 inhibitory activity (IC50against JAK1?=?0.08–0.15?μM; JAK1-selectivity?=?26–40 fold vs JAK2, 12–23 fold vs JAK3, and 38–54 fold vs Tyk2) along with significantly increased lipophilicity (3.3–15.8 times) as well as membrane permeability (6.3–12 times).
