1384427-82-0 Usage
General Description
The chemical 2-(methoxymethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-amine, also known as a selective GABA receptor modulator, is a psychoactive drug with sedative and anxiolytic effects. It is a derivative of the tetrahydrotriazolopyridine class of compounds and is structurally similar to other benzodiazepine drugs. It acts as a positive allosteric modulator of the GABA-A receptor, enhancing the inhibitory action of the neurotransmitter GABA in the brain. This leads to sedative, anxiolytic, and muscle relaxant effects, making it useful in the treatment of conditions such as anxiety, insomnia, and seizures. However, it also has the potential for abuse and dependence, and its use is strictly regulated.
Check Digit Verification of cas no
The CAS Registry Mumber 1384427-82-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,4,4,2 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1384427-82:
(9*1)+(8*3)+(7*8)+(6*4)+(5*4)+(4*2)+(3*7)+(2*8)+(1*2)=180
180 % 10 = 0
So 1384427-82-0 is a valid CAS Registry Number.
1384427-82-0Relevant articles and documents
Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]- and [1,5-a]pyridine cores
Mishchuk, Alexander,Shtil, Natalia,Poberezhnyk, Mykola,Nazarenko, Konstiantyn,Savchenko, Timur,Tolmachev, Andrey,Krasavin, Mikhail
supporting information, p. 1056 - 1059 (2016/02/16)
Six sets of functionalized building blocks based on 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine as well as 5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine cores have been prepared. These compounds are non-flat, bicyclic heterocycles that are likely to find utility as privileged motifs for lead-like compound design. One set of building blocks, (5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ylmethyl)amines, proved useful as a scaffold for developing compounds that stimulate glucagon-like peptide-1 (GLP-1) secretion and are novel anti-diabetes drug leads.
