138472-01-2

Basic information

• Product Name: NOR-3
• Synonyms: NOR-3;4-ETHYL2-E-(HYDROXYIMINO)-5-NITRO-3E-HEXENAMIDE;FK409;(+/-)-(E)-ETHYL-2-[(E)-HYDROXYIMINO]-5-NITRO-3-HEXENEAMIDE;(+/-)-(E)-4-ETHYL-2-[(E)-HYDROXYIMINO]-5-NITRO-3-HEXENAMIDE
• CAS NO: 138472-01-2
• Molecular Formula: C8H13N3O4
• Molecular Weight: 215.21
• Mol File: 138472-01-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.2 °C at 760 mmHg
• Flash Point: 212.7 °C
• Appearance: /
• Density: 1.33 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: NOR-3(CAS DataBase Reference)
• NIST Chemistry Reference: NOR-3(138472-01-2)
• EPA Substance Registry System: NOR-3(138472-01-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 138472-01-2(Hazardous Substances Data)

Usage

Description

NOR-3, also known as FK-409, is a cell-permeable nitric oxide (NO) donor. It is a compound that releases nitric oxide in a time-dependent manner, with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. NOR-3 has been found to have various applications in different industries due to its unique properties.

Uses

Used in Pharmaceutical Industry:
NOR-3 is used as a NO donor for its ability to release nitric oxide, which has various biological effects. It is particularly useful in the development of drugs targeting conditions that can benefit from the modulation of nitric oxide levels.
Used in Research Applications:
NOR-3 is used as a research tool for studying the role of nitric oxide in various biological processes. Its controlled release of NO makes it an ideal compound for investigating the effects of nitric oxide on cellular functions and signaling pathways.
Used in Diagnostic Applications:
NOR-3 can be used in diagnostic applications to measure the effects of nitric oxide on platelet aggregation. With an IC50 value of 4.9 μM for the inhibition of platelet aggregation, it can help in understanding the underlying mechanisms of platelet function and the potential for therapeutic intervention.

Upstream product

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Relevant articles and documents

New reagents for controlled release of nitric oxide. Structure-stability relationships

The synthesis and structure-stability relationships of a series of novel FK409 derivatives are described. The rates of decomposition in aqueous solution (pH 8.0, 30°C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.

Nitro aliphatic compounds, process for preparation thereof and use thereof

New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.