138514-31-5Relevant articles and documents
Cefditoren pivoxil intermediate preparation method
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Paragraph 0024; 0027, (2016/11/28)
The invention discloses a cefditoren pivoxil intermediate preparation method. The method includes steps: 1) in existence of sodium iodide, allowing contact reaction of GCLE and triphenylphosphine in a first mixed solvent, cooling to 8-10 DEG C, adding sod
AN IMPROVED PROCESS FOR THE PREPARATION OF CEFDITOREN
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Page 9, (2010/02/10)
The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a compound of the formula (III) using TPP and sodium iodide in the presence of THF, water, and base; ii) reacting the compound of formula (III) with 4-methyl-5-formyl-thiazole to produce a compound of formula (IV); iii) deesterifying the compound of the formula (IV) to yield compound of formula (V); iv) converting the compound of formula (V) to compound of formula (VI) in the presence of a base and solvent; v) converting the compound of formula (VI) into compound of formula (VII) by enzymatic hydrolysis; and vi) reacting compound of formula (VII) with compound of formula (VIII) in the presence of solvent and base to produce compound of formula (I).