138696-49-8

Basic information

• Product Name: 2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)acrylaldehyde
• Synonyms: 2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)acrylaldehyde
• CAS NO: 138696-49-8
• Molecular Weight: 266.385
• Mol File: 138696-49-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)acrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)acrylaldehyde(138696-49-8)
• EPA Substance Registry System: 2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)acrylaldehyde(138696-49-8)

Safety Data

• Hazardous Substances Data: 138696-49-8(Hazardous Substances Data)

Upstream product

• 41467-27-0 3,3-bis(methylthio)-1-(p-tolyl)prop-2-en-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 75-15-0 carbon disulfide 
• 53073-02-2 sodium salt of p-toluoylacetaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 1010121-62-6 5-(4-methylbenzoyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 1099823-54-7 5-(4-methylphenyl)-3-(methylsulfanyl)-4-isoxazolecarbonitrile 
• 1099823-61-6 5-(4-methylphenyl)-3-(methylsulfanyl)-4-isoxazolecarbaldehyde oxime 
• 96219-89-5 (5-amino-1H-pyrazol-4-yl)(4-methylphenyl)methanone 
• 1639452-85-9 3-amino-2-(4-methylbenzoyl)-3-(methylsulfanyl)-2-propenal 
• 1293365-38-4 (2-(ethylamino)-5-phenylfuran-3-yl)(p-tolyl)methanone 
• 1293365-27-1 (2-(methylthio)-5-phenylfuran-3-yl)(p-tolyl)methanone 
• 1293365-19-1 (E)-2-(bis(methylthio)methylene)-4-phenyl-1-(p-tolyl)but-3-en-1-one 
• 881889-92-5 2-[2-(4-methylbenzoyl)-3,3-bis(methylsulfanyl)-2-propenylidene]malononitrile 

Relevant articles and documents

Synthesis of 3-aroylnicotinonitriles from aroylketene dithioacetals

The Knoevenagel adducts of 2-aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes and malononitrile were cyclized in the presence of diisopropylamine to afford 5-aroyl-2,6-bis(methylsulfanyl)nicotinonitriles. Cyclization in the presence of aqueous ammonia gave 2-am

A convenient preparation of 2-aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes and their application in the synthesis of 5-aroyl-2-oxo-1,2-dihydro-2- pyridinecarbonitriles

The reaction of aroylketene dithioacetals 1 with Vilsmeier-Haack reagent, prepared from POCl3 and DMF, under mild conditions gave 2-aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes 2 in excellent yields. Cyclization of 2-[2-aroyl-3,3-bis(methylsulfan