13880-05-2Relevant articles and documents
Brown,Tovet
, p. 2595 (1978)
A Serum-Tolerant Hydroxyl-Modified Polyethylenimine as Versatile Carriers of pDNA/siRNA
Dong, Xuan,Lin, Lin,Chen, Jie,Guo, Zhaopei,Tian, Huayu,Li, Yuce,Wei, Yen,Chen, Xuesi
, p. 512 - 522 (2013)
The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacity than PEI25k. Specially, the transfection efficiency of PT26/DNA is 29-fold higher than that of PEI25k in HeLa cells in serum-containing medium. The PTn/siRNA complexes show superior knockdown effect in CT26 cells in serum-containing medium. In addition, flow cytometry analysis shows that the PTns can efficiently mediate the entry of nucleic acids into the cell. Thus, PTns are potentially applicable as non-viral carriers of nucleic acids and warrant further development for use in gene therapy. A series of serum-tolerant PTn conjugates, by introduction of hydroxyl groups onto PEI25k, is designed as dual carriers for nucleic acids delivery. The transfection efficiency of PTn can be up to 29.1-fold higher than that of PEI25k in the serum-containing medium. Meanwhile, PTn with higher endocytosis is more effective in luciferase knockdown compared to PEI25k in the serum-containing medium.
DENDRI-TAC AND THEIR USE AS THERANOSTICS
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Page/Page column 57, (2016/12/07)
The present invention relates to novel amphiphilic dendrimers, hereafter denoted Dendri-TAC. The present invention also relates to perfluorocarbon nanoemulsions stabilized by these amphiphilic dendrimers and their uses for in vivo diagnostic and/or for therapy, notably as theranostic tools, for detection and/or treatment of cancer.
Ink composition for inkjet printing, ink set, and image forming method
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, (2014/10/15)
The invention provides an ink composition for inkjet printing, the ink composition containing water, a coloring material, a polymerizable compound, a polymerization initiator represented by the following Formula (X), and polymer particles having a glass transition temperature of 90°C or higher, a mass ratio of the polymer particles to the polymerization initiator represented by Formula (X) being in a range of from 1:10 to 10:1 1 [in Formula (X), each of RX1, RX2, RX3, and RX4 independently represents a hydrogen atom or a substituent; and n represents an integer from 1 to 4].