13893-53-3

Basic information

• Product Name: 2-Amino-2,3-dimethylbutyronitrile
• Synonyms: 2-AMINO-2,3-DIMETHYL-BUTYRONITRILE;2-AMINO-2,3-DIMETHYLBUTANENITRILE;2-AMino-2,3-diMethyl-butyronitril;2-Amino-2,3-dimethylbutyronitrile, 1-Amino-1,2-dimethylprop-1-yl cyanide;Butanenitrile, 2-aMino-2,3-diMethyl-
• CAS NO: 13893-53-3
• Molecular Formula: C₆H₁₂N₂
• Molecular Weight: 112.17
• Mol File: 13893-53-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 43 °C
• Flash Point: 58.8 °C
• Appearance: colourless to light yellow liquid
• Density: 0.896 g/cm³
• Vapor Pressure: 1.26mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 5.18±0.25(Predicted)
• CAS DataBase Reference: 2-Amino-2,3-dimethylbutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2,3-dimethylbutyronitrile(13893-53-3)
• EPA Substance Registry System: 2-Amino-2,3-dimethylbutyronitrile(13893-53-3)

Safety Data

• Hazardous Substances Data: 13893-53-3(Hazardous Substances Data)

Usage

Uses

2-Amino-2,3-dimethylbutanenitrile is used by Rhodococcus qingshengii in the biosynthesis of 2-Amino-2,3-dimethylbutyramide, an important intermediate in the synthesis of potent imadazoline herbicides. In addition, it is used to prepare new chiral ligands.

InChI:InChI=1/C6H12N2/c1-5(2)6(3,8)4-7/h5H,8H2,1-3H3/p+1/t6-/m0/s1

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 773837-37-9 sodium cyanide 
• 87-69-4 L-Tartaric acid 
• 90376-97-9 (R)2-amino-2,3-dimethibutyronitrile 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 107640-56-2 N-(1-cyano-1,2-dimethylpropyl)benzamide 
• 40963-14-2 2-amino-2,3-dimethylbutyramide 
• 81334-34-1 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid 
• 81334-34-1 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid 
• 81335-37-7 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-Yl]-3-quinolinecarboxylic acid 
• 90377-00-7 (-)-(S)-2-amino-2,3-dimethylbutanamide 
• 63081-72-1 N-(1-cyano-1,2-dimethylpropyl)phthalamic acid 
• 880133-98-2 C₁₇H₂₃IN₂O 
• 115852-48-7 N-(1-cyano-1,2-dimethyl-propyl)-2-(2,4-dichlorophenoxy)-propionamide 
• 203314-42-5 C₁₆H₂₂N₂O 
• 110863-17-7 (S,S)-ammonium hydrogen tartrate 
• 166538-35-8 2-(4-Nitrobenzoylamino)-2,3-dimethylbutanamide 

Relevant articles and documents

Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures

A central problem for the prebiotic synthesis of biological amino acids and nucleotides is to avoid the concomitant synthesis of undesired or irrelevant by-products. Additionally, multistep pathways require mechanisms that enable the sequential addition of reactants and purification of intermediates that are consistent with reasonable geochemical scenarios. Here, we show that 2-aminothiazole reacts selectively with two- and three-carbon sugars (glycolaldehyde and glyceraldehyde, respectively), which results in their accumulation and purification as stable crystalline aminals. This permits ribonucleotide synthesis, even from complex sugar mixtures. Remarkably, aminal formation also overcomes the thermodynamically favoured isomerization of glyceraldehyde into dihydroxyacetone because only the aminal of glyceraldehyde separates from the equilibrating mixture. Finally, we show that aminal formation provides a novel pathway to amino acids that avoids the synthesis of the non-proteinogenic α,α-disubstituted analogues. The common physicochemical mechanism that controls the proteinogenic amino acid and ribonucleotide assembly from prebiotic mixtures suggests that these essential classes of metabolite had a unified chemical origin.

Fenoxanil original drug synthesis method

The invention relates to a fenoxanil original drug synthesis method. The method includes: employing an organic solvent to synthesize an intermediate 2-(2, 4-dichlorophenoxy)propionic acid by one step, and then synthesizing fenoxanil. Therefore, the condensation yield reaches more than 96%. The method provided by the invention can substantially reduce wastewater and realize clean production, and has very good practical application effect.

Synthesis of enantiopure fmoc-#-methylvaline

An efficient synthesis of enantiopure Fmoc-α-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved using a chiral amine, (S)- 1,2,3,4-tetrahydro-1-naphthylamine to give the desired, enantiopure S