139026-66-7

Basic information

• Product Name: JMV 449
• Synonyms: [LYS8-PSI(CH2NH)-LYS9]NEUROTENSIN (8-13);(LYS8-(R)-LYS9)-NEUROTENSIN (8-13);JMV 449;LYS-PSI(CH2NH)-LYS-PRO-TYR-ILE-LEU;H-LYS-(R)-LYS-PRO-TYR-ILE-LEU-OH;M.W. 746.96 C38H66N8O7;L-Lysψ(CH2NH)-L-Lys-L-Pro-L-Tyr-L-Ile-L-Leu-OH;H-Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH
• CAS NO: 139026-66-7
• Molecular Formula: C38H66N8O7
• Molecular Weight: 746.98
• Product Categories: Neuromedins and related
• Mol File: 139026-66-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1044.2°Cat760mmHg
• Flash Point: 585.3°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: -15°C
• CAS DataBase Reference: JMV 449(CAS DataBase Reference)
• NIST Chemistry Reference: JMV 449(139026-66-7)
• EPA Substance Registry System: JMV 449(139026-66-7)

Safety Data

• Hazardous Substances Data: 139026-66-7(Hazardous Substances Data)

Usage

Description

JMV 449 is a pseudopeptide analog of neurotensin-(8-13), which is a naturally occurring peptide in the body. It is known for its highly potent and long-lasting hypothermic and analgesic effects in mice, making it a potential candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
JMV 449 is used as a therapeutic agent for its hypothermic and analgesic properties. The expression is: JMV 449 is used as a therapeutic agent for its ability to induce hypothermia and provide pain relief in mice.
Used in Research and Development:
JMV 449 is used as a research tool to study the effects of neurotensin-(8-13) analogs on body temperature regulation and pain perception. The expression is: JMV 449 is used as a research tool for investigating the mechanisms underlying its hypothermic and analgesic effects in mice.
Used in Drug Development for Pain Management:
JMV 449 is used as a potential drug candidate for the development of new pain management therapies, due to its potent and long-lasting analgesic effects. The expression is: JMV 449 is used as a drug candidate for the development of novel pain management therapies, leveraging its potent and long-lasting pain-relieving properties.
Used in Drug Development for Hypothermia Treatment:
JMV 449 is used as a potential drug candidate for the development of therapies targeting hypothermia, which can be beneficial in various medical conditions. The expression is: JMV 449 is used as a drug candidate for the development of hypothermia treatment options, based on its ability to induce long-lasting hypothermia in mice.

InChI:InChI=1/C38H66N8O7/c1-5-25(4)33(36(50)44-31(38(52)53)21-24(2)3)45-34(48)30(22-26-14-16-28(47)17-15-26)43-35(49)32-13-10-20-46(32)37(51)29(12-7-9-19-40)42-23-27(41)11-6-8-18-39/h14-17,24-25,27,29-33,42,47H,5-13,18-23,39-41H2,1-4H3,(H,43,49)(H,44,50)(H,45,48)(H,52,53)/t25-,27-,29-,30-,31-,32-,33-/m0/s1