1390645-40-5Relevant articles and documents
Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists
Zhang, Jun,Wang, Jin-Liang,Zhou, Zhi-Ming,Li, Zhi-Huai,Xue, Wei-Zhe,Xu, Di,Hao, Li-Ping,Han, Xiao-Feng,Fei, Fan,Liu, Ting,Liang, Ai-Hua
, p. 4208 - 4216 (2012/08/28)
A series of 6-substituted carbamoyl benzimidazoles were designed and synthesised as new nonpeptidic angiotensin II AT1 receptor antagonists. The preliminary pharmacological evaluation revealed a nanomolar AT1 receptor binding affinity for all compounds in the series, and a potent antagonistic activity in an isolated rabbit aortic strip functional assay for compounds 6f, 6g, 6h and 6k was also demonstrated. Furthermore, evaluation in spontaneous hypertensive rats and a preliminary toxicity evaluation showed that compound 6g is an orally active AT1 receptor antagonist with low toxicity.