1391001-83-4

Basic information

• Product Name: (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine
• Synonyms: (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine
• CAS NO: 1391001-83-4
• Molecular Weight: 365.308
• Mol File: 1391001-83-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine(1391001-83-4)
• EPA Substance Registry System: (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine(1391001-83-4)

Safety Data

• Hazardous Substances Data: 1391001-83-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1388651-04-4 (2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid 
• 1391001-99-2 2-((1-(trityloxy)but-3-en-2-yl)oxy)acetaldehyde oxime 
• 1391001-98-1 2-((1-(trityloxy)but-3-en-2-yl)oxy)acetaldehyde 
• 1391001-97-0 tert-butyl 2-((1-(trityloxy)but-3-en-2-yl)oxy)acetate 
• 1391001-82-3 (4aS,5S,7aS)-5-(difluoromethyl)-7a-(2,3-difluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine 
• 1391001-81-2 N-((4aS,5S,7aS)-5-(difluoromethyl)-7a-(2,3-difluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide 
• 1391001-80-1 N-((4aS,5S,7aS)-7a-(2,3-difluorophenyl)-5-formyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide 
• 1388651-16-8 N-((4aS,5S,7aS)-7a-(2,3-difluorophenyl)-5-(hydroxymethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide 
• 1388651-08-8 N-(((3S,4R,5S)-3-(2,3-difluorophenyl)-4-(hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide 
• 1388651-03-3 ((2S,3R,4S)-4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol 
• 1388651-58-8 1-(2,3-difluorophenyl)-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone oxime 
• 1388651-55-5 1-(2,3-difluorophenyl)-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone 
• 38573-88-5 1-bromo-2,3-difluorobenzene 

Downstream Products

• 1391001-84-5 tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 
• 1391001-85-6 tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2,3-difluorophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 
• 1391001-86-7 tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-(5-methoxypyrazine-2-carboxamido)phenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 
• 1391001-76-5 N-(3-((4aS,5S,7aS)-2-amino-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4,5-difluorophenyl)-5-methoxypyrazine-2-carboxamide 

Relevant articles and documents

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.