1391194-45-8

Basic information

• Product Name: 5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate
• Synonyms: Prasugrel IMpurity 1;Prasugrel IMpurity I
• CAS NO: 1391194-45-8
• Molecular Formula: C20H21NO3S
• Molecular Weight: 355.45064
• Mol File: 1391194-45-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate(1391194-45-8)
• EPA Substance Registry System: 5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate(1391194-45-8)

Safety Data

• Hazardous Substances Data: 1391194-45-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate" is a complex organic molecule with a cyclopropyl and phenylethyl group attached to a tetrahydrothieno ring. It also contains an acetate group. 5-(2-cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate belongs to the class of heterocyclic compounds, which are organic compounds containing at least one carbon atom in the ring structure replaced by an atom of any other element. The specific structure and properties of this compound may have potential applications in pharmaceuticals, chemical research, or other industrial purposes.

Upstream product

• 115473-15-9 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride 
• 34650-68-5 2-bromo-1-cyclopropyl-2-phenylethanone 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Treatment effect of 4,5,6,7-tetrahydrothiophene-[3,2-c] pyridine derivative on thrombi

The invention provides a treatment effect of a 4,5,6,7-tetrahydrothiophene-[3,2-c] pyridine derivative on thrombi. The 4,5,6,7-tetrahydrothiophene-[3,2-c] pyridine derivative has the following generalformula structure: (with reference to the specification), wherein R represents C1-C6 alkyl acyloxy; R and R can be the same or different, and are respectively independently selected from C1-C6 alkyl, C1-C6 alkoxy, a halo substituent of C1-C6 alkyl, C1-C6 naphthenic base, C1-C6 alkyl sulphanyl, aryl, a substituent group of aryl, heteroaryl, a substituent group of heteroaryl or heterocyclic alkyl. According to the invention, the new 4,5,6,7-tetrahydrothiophene-[3,2-c] pyridine derivative is synthesized, which is a blood platelet adenosine diphosphate receptor inhibitor and is used fortreating thrombi; active molecules are formed in a body and are combined with a blood platelet P2Y12 receptor to exert effects; the 4,5,6,7-tetrahydrothiophene-[3,2-c] pyridine derivative has an excellent anticoagulant effect and meanwhile, has excellent bioavailability.

Identification and synthesis of impurities formed during prasugrel hydrochloride preparation

Prasugrel hydrochloride (1), an important platelet inhibitor is used for the reduction of thrombotic cardiovascular events. During laboratory I optimization and later its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation patterns in LC-MS. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities. Present study will be of immense help to others to obtain chemically pure prasugrel hydrochloride.