1391512-50-7

Basic information

• Product Name: (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone
• Synonyms: (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone,99%;2-Oxazolidinone, 4-(phenylmethyl)-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-, (4R,5S)-
• CAS NO: 1391512-50-7
• Molecular Formula: C18H14F13NO2
• Molecular Weight: 523.29
• Mol File: 1391512-50-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 90-95°C
• Appearance: /
• CAS DataBase Reference: (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone(1391512-50-7)
• EPA Substance Registry System: (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone(1391512-50-7)

Safety Data

• Hazardous Substances Data: 1391512-50-7(Hazardous Substances Data)

Usage

Description

(4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone is a chiral fluorous support used in conventional and high-throughput organic synthesis. It is characterized by its ability to induce high stereoselectivity in various chemical reactions, such as aldol reactions, cycloadditions, and conjugate additions involving N-acyl derivatives. The presence of a fluorous chain allows for rapid and efficient isolation of products through solid phase extraction, using minimal amounts of common solvents. Additionally, it belongs to a class of catalytic ligands that, when used with a reducing agent, exhibit enantioselectivity in the reduction of a wide range of substrates.

Uses

Used in Organic Synthesis:
(4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone is used as a chiral fluorous support for enhancing stereoselectivity in various organic reactions, such as aldol reactions, cycloadditions, and conjugate additions. Its fluorous chain enables efficient product isolation and reduces the use of common solvents.
Used in Pharmaceutical Industry:
(4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone is used as a class of catalytic ligands in the pharmaceutical industry. When combined with a reducing agent, it exhibits enantioselectivity in the reduction of a wide range of substrates, which is crucial for the development of chiral drugs with desired biological activities.
Used in High-Throughput Screening:
In the field of drug discovery and development, (4R,5S)-(+)-4-Benzyl-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-oxazolidinone is utilized in high-throughput screening processes. Its ability to induce high stereoselectivity in various chemical reactions makes it a valuable tool for identifying potential drug candidates with specific stereochemical properties.