1392308-35-8

Basic information

• Product Name: 2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one
• Synonyms: 2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one
• CAS NO: 1392308-35-8
• Molecular Weight: 429.429
• Mol File: 1392308-35-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one(1392308-35-8)
• EPA Substance Registry System: 2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one(1392308-35-8)

Safety Data

• Hazardous Substances Data: 1392308-35-8(Hazardous Substances Data)

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 459-57-4 4-fluorobenzaldehyde 
• 107-91-5 cyanoacetic acid amide 

Relevant articles and documents

Polyethylene glycol (PEG-400): An efficient green reaction medium for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones under catalyst-free conditions

A simple and an efficient eco-friendly methodology has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones in excellent yields under catalyst-free-conditions using inexpensive and non-toxic polyethylene glycol (PEG-400) medium. This new protocol offers an environmental acceptability, shorter reaction time, room temperature, low cost, high yields, and recyclability of the PEG-400 medium are the important features. This method provides a green and much improved protocol over the existing methods.

A catalyst-free reaction in water: Synthesis of benzo[4,5]imidazo[1,2-a] pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives

An environmentally benign and efficient method has been developed for the synthesis of a series of benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)- one derivatives in aqueous media under catalyst-free conditions by simply combining 2-aminobenzimidazole, aldehyde, and cyanoacetamide. The advantages of this method are that it is catalyst-free, has an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign.