1393642-93-7

Basic information

• Product Name: C₁₈H₂₈O₃
• Synonyms: C₁₈H₂₈O₃
• CAS NO: 1393642-93-7
• Molecular Weight: 292.419
• Mol File: 1393642-93-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₈O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₈O₃(1393642-93-7)
• EPA Substance Registry System: C₁₈H₂₈O₃(1393642-93-7)

Safety Data

• Hazardous Substances Data: 1393642-93-7(Hazardous Substances Data)

Upstream product

• 109232-37-3 5-chloro-2,2-dimethylpentanoic acid isobutyl ester 
• 95-48-7 ortho-cresol 

Downstream Products

• 1225796-29-1 2,2-dimethyl-5-(o-tolyloxy)pentanoic acid 

Relevant articles and documents

Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study

Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A series of new gemfibrozil derivatives were synthesized and evaluated for sGC activation. The structure-activity relationship study identified the positions in gemfibrozil's scaffold that are detrimental for sGC activation and those that are amendable for optimizing modifications. Compared with gemfibrozil, compounds 7c and 15b were more potent activators of cGMP-forming activity of purified sGC and exhibited enhanced relaxation of preconstricted mouse thoracic aorta rings. These studies established the overall framework needed for futher improvement of sGC activators based on gemfibrozil scaffold.