1393726-78-7Relevant articles and documents
Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones
Piron, Karel,Kenis, Sara,Verniest, Guido,Surmont, Riccardo,Thuring, Jan Willem,Ten Holte, Peter,Deroose, Frederik,De Kimpe, Norbert
, p. 6941 - 6947 (2012/08/29)
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.
