1394148-18-5

Basic information

• Product Name: 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride
• Synonyms: 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride
• CAS NO: 1394148-18-5
• Molecular Weight: 397.969
• Mol File: 1394148-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride(1394148-18-5)
• EPA Substance Registry System: 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride(1394148-18-5)

Safety Data

• Hazardous Substances Data: 1394148-18-5(Hazardous Substances Data)

Upstream product

• 19492-96-7 1-benzo[b]thiophen-3-yl-propan-1-one 
• 79156-10-8 1-(benzo[b]thiophen-3-yl)-2-bromopropan-1-one 
• 95-15-8 Benzo[b]thiophene 
• 1200805-98-6 1-(benzo[b]thiophen-3-yl)-2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one 

Relevant articles and documents

Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

A series of arylalkanol-piperidine derivatives was synthesized, and their triple reuptake inhibition and in vivo activities have been evaluated. Among them, compounds 2a, 2j, 2k, 2m and 2n exhibited high potency for 5-HT, NA and DA transporters. Optimized compounds 2j and 2m showed significant reduction of immobility time compared to that of vehicle in the mouse tail suspension test (TST) test at doses ranging from 10 to 50 mg/kg po, and were not generally motor stimulants at 50 mg/kg dose. In addition, compounds 2j and 2m displayed desirable pharmacokinetic properties in SD rats.