1397682-63-1 Usage
Description
Propargyl-PEG5-beta-D-galactose is a biocompatible crosslinker designed for use in click chemistry, featuring a propargyl group and beta-D-galactose. The propargyl group enables selective and efficient conjugation with azide-containing molecules through copper-catalyzed azide-alkyne click chemistry, forming stable triazole linkages. The presence of beta-D-galactose enhances solubility in aqueous environments and improves the selectivity of PEGylation reactions, making it a versatile tool for various applications in the biotechnology and pharmaceutical industries.
Uses
Used in Bioconjugation:
Propargyl-PEG5-beta-D-galactose is used as a crosslinker for bioconjugation, allowing the selective and efficient attachment of azide-bearing biomolecules, such as proteins, peptides, or nucleic acids, through stable triazole linkages. This enhances the stability, solubility, and bioavailability of the conjugated biomolecules, making it suitable for applications in drug delivery, diagnostics, and therapeutics.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Propargyl-PEG5-beta-D-galactose is used as a component in the development of drug delivery systems. Its ability to form stable triazole linkages with azide-modified drugs allows for the creation of targeted and controlled-release drug conjugates. This can improve the efficacy and reduce the side effects of various therapeutic agents.
Used in Diagnostics:
Propargyl-PEG5-beta-D-galactose is used as a labeling agent in diagnostic applications, such as immunoassays and molecular imaging. The propargyl group can be used to attach detection moieties, like fluorescent dyes or radioactive isotopes, to biomolecules, enabling their detection and quantification in biological samples.
Used in Material Science:
In the field of material science, Propargyl-PEG5-beta-D-galactose can be employed as a component in the development of biocompatible and biodegradable materials. Its ability to form stable linkages with other molecules can be utilized to create hydrogels, scaffolds, or other structures with tailored properties for tissue engineering or regenerative medicine applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1397682-63-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,7,6,8 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1397682-63:
(9*1)+(8*3)+(7*9)+(6*7)+(5*6)+(4*8)+(3*2)+(2*6)+(1*3)=221
221 % 10 = 1
So 1397682-63-1 is a valid CAS Registry Number.
1397682-63-1Relevant articles and documents
NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging
Chen, Shiguang,Fang, Yanfen,Zhu, Qiwen,Zhang, Wanli,Zhang, Xiongwen,Lu, Wei
, p. 81894 - 81901 (2016/09/09)
Given the increased glucose uptake in cancer cells than normal cells, near-infrared (NIR) fluorescent glucose analogues have been previously synthesized and applied in cancer cell imaging. However, most NIR dyes usually have one or more charge in their structures, which may cause low cell membrane permeability and hamper their application in cell imaging. Here we report the synthesis and characterization of a series of DCPO-conjugated glucose analogues (N0-N4), which have no charge in their structures and have different lengths of the spacer arm. Experiments in different cancer cell lines showed the uptake of N0-N4 was dependent on the protein levels of GLUT-1. The distance between the dyes and glucose was adjusted by the length of PEG. Of these five glucose analogues, the length of the linker in N2 which contains a diethylene glycol was the most appropriate spacer arm, a longer or shorter linker exhibited reduced cellular uptake efficiency. Moreover, the uptake of DCPO-conjugated glucose analogues could be inhibited by phloretin, a GLUT-1 inhibitor or competitively inhibited by unlabeled d-glucose. Therefore, our study has reported a novel type of NIR-conjugated glucose analogues, whose cell permeability ensured the potential application for cancer cell bioimaging in the NIR region. We also demonstrated, for the first time, that the length of the linker between the dyes and glucose was also an important factor that will affect the delivery efficiency of the glucose analogues to cells.
