1398179-24-2

Basic information

• Product Name: ethyl 2-(2-bromophenyl)-2-diazoacetate
• Synonyms: ethyl 2-(2-bromophenyl)-2-diazoacetate
• CAS NO: 1398179-24-2
• Molecular Weight: 269.098
• Mol File: 1398179-24-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-bromophenyl)-2-diazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-bromophenyl)-2-diazoacetate(1398179-24-2)
• EPA Substance Registry System: ethyl 2-(2-bromophenyl)-2-diazoacetate(1398179-24-2)

Safety Data

• Hazardous Substances Data: 1398179-24-2(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 

Downstream Products

• 1398180-70-5 ethyl 2-(2-bromophenyl)-3,3,3-trifluoropropanoate 
• 92-52-4 biphenyl 

Relevant articles and documents

(HETERO)ARYL-METHYL-THIO-BETA-D-GALACTOPYRANOSIDE DERIVATIVES

The present invention relates to compounds of Formula (I) wherein Ar1, Ar2, R1a, R1b, and R2 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Three-Component Ring-Opening Reactions of Cyclic Ethers, α-Diazo Esters, and Weak Nucleophiles under Metal-Free Conditions

A protocol for three-component reactions of cyclic ethers, α-diazo esters, and weak nitrogen, oxygen, carbon, and sulfur nucleophiles (pKa = 2.2-14.8) to afford a variety of structurally complex α-oxyalkylated esters is reported. These reactions involve intermolecular activation of the cyclic ether (present in excess) by the α-diazo ester to form an oxonium ylide under metal-free conditions, followed by ring opening by the nucleophile.

Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.