1398523-46-0

Basic information

• Product Name: C₁₅H₁₁Br₃N₂O
• Synonyms: C₁₅H₁₁Br₃N₂O
• CAS NO: 1398523-46-0
• Molecular Weight: 474.977
• Mol File: 1398523-46-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₁Br₃N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₁Br₃N₂O(1398523-46-0)
• EPA Substance Registry System: C₁₅H₁₁Br₃N₂O(1398523-46-0)

Safety Data

• Hazardous Substances Data: 1398523-46-0(Hazardous Substances Data)

Upstream product

• 90-59-5 3,5-Dibromosalicylaldehyde 
• 99-90-1 para-bromoacetophenone 
• 110829-99-7 C₁₅H₉Br₃O₂ 

Downstream Products

• 1398523-37-9 C₁₇H₁₃Br₃N₂O₂ 

Relevant articles and documents

Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors

A series of novel 4,5-dihydropyrazole derivatives (3a-3t) containing hydroxyphenyl moiety as potential V600E mutant BRAF kinase (BRAF V600E) inhibitors were designed and synthesized. Docking simulation was performed to insert compounds 3d (1-(5-(5-chloro-2-hydroxyphenyl)-3-(p- tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone) and 3m (1-(3-(4-chlorophenyl)-5-(3, 5-dibromo-2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone) into the crystal structure of BRAFV600E to determine the probable binding model, respectively. Based on the preliminary results, compound 3d and 3m with potent inhibitory activity in tumor growth may be a potential anticancer agent. Results of the bioassays against BRAFV600E, MCF-7 human breast cancer cell line and WM266.4 human melanoma cell line all showed several compounds had potent activities IC50 value in low micromolar range, among them, compound 3d and compound 3m showed strong potent anticancer activity, which were proved by that 3d: IC50 = 1.31 μM for MCF-7 and IC50 = 0.45 μM for WM266.5, IC50 = 0.22 μM for BRAFV600E, 3m: IC50 = 0.97 μM for MCF-7 and IC50 = 0.72 μM for WM266.5, IC50 = 0.46 μM for BRAFV600E, which were comparable with the positive control Erlotinib.