1399679-51-6

Basic information

• Product Name: 5-(((S)-2-methyl-3-((2R,3R)-3-((2S,3S)-3-((triethylsilyl)oxy)pentan-2-yl)oxiran-2-yl)propyl)sulfonyl)-1-phenyl-1H-tetrazole
• CAS NO: 1399679-51-6
• Molecular Weight: 508.757
• Mol File: 1399679-51-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(((S)-2-methyl-3-((2R,3R)-3-((2S,3S)-3-((triethylsilyl)oxy)pentan-2-yl)oxiran-2-yl)propyl)sulfonyl)-1-phenyl-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(((S)-2-methyl-3-((2R,3R)-3-((2S,3S)-3-((triethylsilyl)oxy)pentan-2-yl)oxiran-2-yl)propyl)sulfonyl)-1-phenyl-1H-tetrazole(1399679-51-6)
• EPA Substance Registry System: 5-(((S)-2-methyl-3-((2R,3R)-3-((2S,3S)-3-((triethylsilyl)oxy)pentan-2-yl)oxiran-2-yl)propyl)sulfonyl)-1-phenyl-1H-tetrazole(1399679-51-6)

Safety Data

• Hazardous Substances Data: 1399679-51-6(Hazardous Substances Data)

Upstream product

• 934497-74-2 (3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol 
• 1399680-07-9 (2S,6S,7S,E)-2,6-dimethyl-7-((triethylsilyl)oxy)non-4-en-1-yl methanesulfonate 
• 95273-27-1 (3S,4S)-4-hydroxy-3-methyl-1-hexene 
• 1399679-64-1 (S)-2-methylpent-4-en-1-yl methanesulfonate 
• 934497-75-3 (2R,3S)-2-((2R,3R)-3-{(2S)-2-methyl-3-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]propyl}oxiran-2-yl)pentan-3-ol 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 445493-23-2 (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-2-{(S,2E,4E)-7-[(2R,3R)-3-{(2R,3S)-3-hydroxypentan-2-yl}oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl}-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate 

Relevant articles and documents

Enantioselective total synthesis of pladienolide B: A potent spliceosome inhibitor

An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis.