13997-69-8

Basic information

• Product Name: N-(4-bromophenyl)prop-2-enamide
• CAS NO: 13997-69-8
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.0699
• Mol File: 13997-69-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 356.6°C at 760 mmHg
• Flash Point: 169.5°C
• Density: 1.504g/cm³
• Vapor Pressure: 2.89E-05mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: N-(4-bromophenyl)prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)prop-2-enamide(13997-69-8)
• EPA Substance Registry System: N-(4-bromophenyl)prop-2-enamide(13997-69-8)

Safety Data

• Hazardous Substances Data: 13997-69-8(Hazardous Substances Data)

Usage

General Description

N-(4-bromophenyl)prop-2-enamide, also known as 4-Bromo-N-phenyl-2-butene-1-amide or 4-Bromophenylacrylamide, is a chemical compound with the molecular formula C9H8BrNO. It is an amide derivative of acrylic acid and contains a phenyl group substituted with a bromine atom and a prop-2-enamide group. N-(4-bromophenyl)prop-2-enamide is commonly used in organic synthesis and medicinal chemistry research for its potential applications as a building block in the synthesis of pharmaceutical compounds. It has been studied for its antimalarial and anti-tumor activities due to its structural resemblance to other biologically active compounds. N-(4-bromophenyl)prop-2-enamide is considered a valuable intermediate in the production of various pharmaceuticals and can be used in the development of new drugs with therapeutic potential.

Upstream product

• 340011-46-3 N-(4-bromophenyl)-3-(phenylsulfonyl)propanamide 
• 590-92-1 3-Bromopropionic acid 
• 106-40-1 4-bromo-aniline 
• 589-87-7 1,4-bromoiodobenzene 
• 79-06-1 2-propenamide 
• 79-10-7 acrylic acid 
• 586-78-7 para-nitrophenyl bromide 
• 814-68-6 acryloyl chloride 

Downstream Products

• 1345610-55-0 3-[4-(3-benzyloxyphenyl)-4-fluoropiperidin-1-yl]-N-(4-bromophenyl)propionamide hydrochloride 
• 340011-51-0 N-allyl N-(4-bromophenyl)acrylamide 
• 108826-66-0 1,4,5,6,7,7-Hexabromo-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (4-bromo-phenyl)-amide 

Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives

Transition-metal-catalyzed asymmetric hydroalkenylation of alkenes provides an atom-economical method to build molecular complexity from easily available materials. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetermination step.

COVALENT TARGETING OF E3 LIGASES

Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

-