1401305-30-3 Usage
General Description
1-isopropyl-3-methyl-1H-1,2,4-triazole is a chemical compound with the molecular formula C5H10N4. It is a derivative of triazole and contains an isopropyl and a methyl group attached to the triazole ring. 1-isopropyl-3-methyl-1H-1,2,4-triazole is commonly used as a fungicide and plant growth regulator, as it has been found to be effective in controlling a wide range of fungal diseases in crops. It works by inhibiting the production of ergosterol, an essential component of fungal cell membranes, leading to the disruption of their growth and reproduction. 1-isopropyl-3-methyl-1H-1,2,4-triazole has also been studied for its potential application in cancer treatment, as it has shown to inhibit the growth of certain cancer cells in laboratory studies. Additionally, it has been used as an intermediate in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1401305-30-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,3,0 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1401305-30:
(9*1)+(8*4)+(7*0)+(6*1)+(5*3)+(4*0)+(3*5)+(2*3)+(1*0)=83
83 % 10 = 3
So 1401305-30-3 is a valid CAS Registry Number.
1401305-30-3Relevant articles and documents
Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 1: Early-Stage Development Routes to the Bromobenzoxazepine Core
Remarchuk, Travis,Angelaud, Rémy,Askin, David,Kumar, Archana,Thompson, Andrew S.,Cheng, Hua,Reichwein, John F.,Chen, Yanping,St-Jean, Frédéric
, p. 775 - 782 (2019/05/24)
Two convergent regioselective routes for the synthesis of the tetracyclic imidazobenzoxazepine triazole 1, a key intermediate toward the synthesis of taselisib, are described. In the first-generation route, a chemoselective Negishi cross-coupling reaction was developed between iodoimidazole 3 and triazole 7, which enabled the delivery of initial kilogram quantities of 1. Because of the inefficiencies in the preparation of the imidazole 3, a second-generation route via a highly regioselective imidazole ring formation between α-chloroketone 11 and aryl amidine 12 was developed. The resulting imidazole 14 provided the handle to efficiently install the seven-membered benzoxazepine ring system in one pot with two-step N-alkylation and SNAr tandem reactions.
